Hi Tony,
Sounds like an interesting engine - a photo would be nice. Do you have a bike for it to live in?
I assume you have the exhaust cam and followers, so the best plan would be to measure the dwell first. That is, for how many degrees are the exhaust valves open? Given the early date, you might find that it is not much more than 180 degrees; perhaps 200 - 220. In this case you might just set the exhaust valves to close at TDC, or maybe 5 degrees after. With atmospheric inlets, it was not fashionable to leave the exhaust open much beyond TDC. (Valve overlap was being used by some racers before WW1, but it was not universally adopted.)
For the ignition, try 35 degrees before TDC fully advanced. Should be plenty.
With the atmospheric inlets, make sure the valve spring tensions are accurately matched, and restrict the opening of the valves so that they don't get too excited and flutter everywhere. Try something like 3/16" maximum opening.
Good luck!
Leon